Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

H2ax  H2A.X variant histone   (Synonyms: gammaH2ax, H2afx, H2A.X, Hist5-2ax)
Results	Reference
1	J:305244 Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Correa IR Jr, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A, N(6)-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. Nat Genet. 2020 Jan;52(1):48-55
1	J:186357 Baleriola J, Suarez T, de la Rosa EJ, DNA-PK promotes the survival of young neurons in the embryonic mouse retina. Cell Death Differ. 2010 Nov;17(11):1697-706
1*	J:236776 Balmus G, Barros AC, Wijnhoven PW, Lescale C, Hasse HL, Boroviak K, le Sage C, Doe B, Speak AO, Galli A, Jacobsen M, Deriano L, Adams DJ, Blackford AN, Jackson SP, Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev. 2016 Oct 1;30(19):2152-2157
1	J:252554 Bianchi FT, Tocco C, Pallavicini G, Liu Y, Verni F, Merigliano C, Bonaccorsi S, El-Assawy N, Priano L, Gai M, Berto GE, Chiotto AM, Sgro F, Caramello A, Tasca L, Ala U, Neri F, Oliviero S, Mauro A, Geley S, Gatti M, Di Cunto F, Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly. Cell Rep. 2017 Feb 14;18(7):1674-1686
1	J:241332 Chen HR, Juan HC, Wong YH, Tsai JW, Fann MJ, Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. Cereb Cortex. 2017 Mar 01;27(3):2289-2302
1	J:206142 Delgado-Esteban M, Garcia-Higuera I, Maestre C, Moreno S, Almeida A, APC/C-Cdh1 coordinates neurogenesis and cortical size during development. Nat Commun. 2013;4:2879
1	J:107426 Dinapoli L, Batchvarov J, Capel B, FGF9 promotes survival of germ cells in the fetal testis. Development. 2006 Apr;133(8):1519-27
1	J:206141 Eguren M, Porlan E, Manchado E, Garcia-Higuera I, Canamero M, Farinas I, Malumbres M, The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat Commun. 2013;4:2880
1	J:158418 Endoh-Yamagami S, Karkar KM, May SR, Cobos I, Thwin MT, Long JE, Ashique AM, Zarbalis K, Rubenstein JL, Peterson AS, A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Dev Biol. 2010 Apr 1;340(1):41-53
1	J:231503 Gergics P, Brinkmeier ML, Camper SA, Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia. Mol Endocrinol. 2015 Apr;29(4):597-612
1	J:165736 Guerquin MJ, Duquenne C, Lahaye JB, Tourpin S, Habert R, Livera G, New testicular mechanisms involved in the prevention of fetal meiotic initiation in mice. Dev Biol. 2010 Oct 15;346(2):320-30
1	J:239361 Guimaraes-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans SM, Zambon AC, HIF1alpha Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Dev Cell. 2015 Jun 08;33(5):507-21
1	J:311067 Gygli PE, Chang JC, Gokozan HN, Catacutan FP, Schmidt TA, Kaya B, Goksel M, Baig FS, Chen S, Griveau A, Michowski W, Wong M, Palanichamy K, Sicinski P, Nelson RJ, Czeisler C, Otero JJ, Cyclin A2 promotes DNA repair in the brain during both development and aging. Aging (Albany NY). 2016 Jul;8(7):1540-70
1*	J:207609 Hilliard SA, Yao X, El-Dahr SS, Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol. 2014 Mar 1;387(1):1-14
1	J:266277 Joseph DB, Chandrashekar AS, Abler LL, Chu LF, Thomson JA, Mendelsohn C, Vezina CM, In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8394-8399
1	J:326251 Kalogeropoulou A, Mougkogianni M, Iliadou M, Nikolopoulou E, Flordelis S, Kanellou A, Arbi M, Nikou S, Nieminuszczy J, Niedzwiedz W, Kardamakis D, Bravou V, Lygerou Z, Taraviras S, Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress. Stem Cell Reports. 2022 Jun 14;17(6):1395-1410
1	J:212924 Katyal S, Lee Y, Nitiss KC, Downing SM, Li Y, Shimada M, Zhao J, Russell HR, Petrini JH, Nitiss JL, McKinnon PJ, Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014 Jun;17(6):813-21
1*	J:231259 Krill KT, Gurdziel K, Heaton JH, Simon DP, Hammer GD, Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex. Mol Endocrinol. 2013 May;27(5):754-68
1	J:178676 Le Bouffant R, Souquet B, Duval N, Duquenne C, Herve R, Frydman N, Robert B, Habert R, Livera G, Msx1 and Msx2 promote meiosis initiation. Development. 2011 Dec;138(24):5393-402
1	J:270064 Little JN, Dwyer ND, p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects. Hum Mol Genet. 2019 Feb 1;28(3):434-447
1	J:224364 Marjanovic M, Sanchez-Huertas C, Terre B, Gomez R, Scheel JF, Pacheco S, Knobel PA, Martinez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Luders J, Stracker TH, CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination. Nat Commun. 2015;6:7676
1	J:184928 Miles DC, van den Bergen JA, Wakeling SI, Anderson RB, Sinclair AH, Western PS, The proto-oncogene Ret is required for male foetal germ cell survival. Dev Biol. 2012 May 1;365(1):101-9
1	J:205283 Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M, Programmed cell senescence during mammalian embryonic development. Cell. 2013 Nov 21;155(5):1104-18
1	J:158526 Naillat F, Prunskaite-Hyyrylainen R, Pietila I, Sormunen R, Jokela T, Shan J, Vainio SJ, Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum Mol Genet. 2010 Apr 15;19(8):1539-50
1	J:145808 Park SY, Lee EJ, Emge D, Jahn CL, Jameson JL, A phenotypic spectrum of sexual development in Dax1 (Nr0b1)-deficient mice: consequence of the C57BL/6J strain on sex determination. Biol Reprod. 2008 Dec;79(6):1038-45
1	J:216158 Rastetter RH, Bernard P, Palmer JS, Chassot AA, Chen H, Western PS, Ramsay RG, Chaboissier MC, Wilhelm D, Marker genes identify three somatic cell types in the fetal mouse ovary. Dev Biol. 2014 Oct 15;394(2):242-52
1	J:339839 Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D, Prin F, Mohun T, Catibog N, Tapia O, Gerace L, Iskratsch T, Shah AM, Stroud MJ, Lem2 is essential for cardiac development by maintaining nuclear integrity. Cardiovasc Res. 2023 Sep 5;119(11):2074-2088
1*	J:209131 Saba R, Wu Q, Saga Y, CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. Dev Biol. 2014 May 15;389(2):173-81
1	J:275391 Simmons AJ, Park R, Sterling NA, Jang MH, van Deursen JMA, Yen TJ, Cho SH, Kim S, Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death. Hum Mol Genet. 2019 Jun 1;28(11):1822-1836
1	J:343800 Souali-Crespo S, Condrea D, Vernet N, Feret B, Klopfenstein M, Grandgirard E, Alunni V, Cerciat M, Jung M, Mayere C, Nef S, Mark M, Chalmel F, Ghyselinck NB, Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis. Development. 2023 Dec 15;150(24)
1	J:298840 Sterling N, Duncan AR, Park R, Koolen DA, Shi J, Cho SH, Benke PJ, Grant PE, Genetti CA, VanNoy GE, Juusola J, McWalter K, Parboosingh JS, Lamont RE, Bernier FP, Smith C, Harris DJ, Stegmann APA, Innes AM, Kim S, Agrawal PB, De novo variants in MPP5 cause global developmental delay and behavioral changes. Hum Mol Genet. 2020 Dec 18;29(20):3388-3401
1	J:332432 Sterling NA, Park JY, Park R, Cho SH, Kim S, An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis. Nat Commun. 2023 Jan 5;14(1):82
1*	J:342123 Sterling NA, Terry BK, McDonnell JM, Kim S, P53 independent pathogenic mechanisms contribute to BubR1 microcephaly. Front Cell Dev Biol. 2023;11:1282182
1	J:343099 Tonosaki M, Fujimori A, Yaoi T, Itoh K, Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis. PLoS One. 2023;18(11):e0294893
1	J:165054 Wang WL, Li Q, Xu J, Cvekl A, Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol Biol Cell. 2010 Jul 15;21(14):2453-68
1*	J:311932 White AK, Baumgartner M, Lee MF, Drake KD, Aquino GS, Kanadia RN, Trp53 ablation fails to prevent microcephaly in mouse pallium with impaired minor intron splicing. Development. 2021 Oct 15;148(20):dev199591
1*	J:87040 Yao HH, DiNapoli L, Capel B, Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads. Development. 2003 Dec;130(24):5895-902
1	J:299730 Zhang L, Jing H, Li H, Chen W, Luo B, Zhang H, Dong Z, Li L, Su H, Xiong WC, Mei L, Neddylation is critical to cortical development by regulating Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26448-26459
1	J:328995 Zhang SF, Dai SK, Du HZ, Wang H, Li XG, Tang Y, Liu CM, The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis. Stem Cell Reports. 2022 Sep 13;17(9):2064-2080